S23 vs RAD-140: Which Works Better?

Written by James C., M.S.(C), PT

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Selective androgen receptor modulators (SARMs) are a class of compounds known for their potential to improve physical performance by increasing muscle mass and strength. S23 and RAD-140 are two popular SARMs that have gained attention in the world of bodybuilding and fitness. While both of these compounds offer their unique benefits, understanding their differences is crucial in choosing the best fit for one’s fitness goals.

S23 vs RAD-140: A Comprehensive Comparison for Performance Enhancement

S23 was initially developed by GTx, a company involved in the development of SARMs for nearly 20 years. It is considered to be one of the strongest SARMs in the family and known to provide significant muscle gains. On the other hand, RAD-140, also known as Testolone, is popular for its ability to enhance muscle mass and strength without carrying severe side effects typically associated with steroids. It is essential to weigh the benefits, side effects, and user opinions when deciding between these two SARMs.

Key Takeaways

  • S23 and RAD-140 are popular SARMs with distinct benefits and side effects.
  • Both compounds can aid in muscle growth and strength, making them attractive options for bodybuilders and athletes.
  • Consideration of research, studies, and user opinions will aid in making an informed decision between these two SARMs.

Understanding S23 and RAD-140

S23 and RAD-140 are both selective androgen receptor modulators (SARMs) that have gained attention for their potential performance-enhancing effects. SARMs are a class of compounds that selectively bind to androgen receptors in the body, leading to an increase in muscle mass and strength. In this section, we will discuss the key features and differences between S23 and RAD-140.

S23 is considered the strongest in a family of SARMs developed by GTx, a company that has been investing in the development of SARMs and other similar research chemicals for nearly 20 years. It is known for its powerful effects on muscle growth, and some users have reported noticeable differences in muscle size, strength, and reduction in body fat.

Strongest in its familyAnabolic to androgenic ratio of 90:1

RAD-140, on the other hand, is known for its anabolic to androgenic ratio of 90:1. This means that the compound has a higher preference for stimulating muscle and strength gains without causing adverse androgenic side effects often seen with traditional steroids. It has been reported to be an effective supplement for maximizing muscle mass growth while minimizing risks.

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Being selective in their action, both SARMs possess several advantages over traditional anabolic steroids. For instance:

It is essential to note that while both S23 and RAD-140 are promising in their ability to aid in muscle gain and strength, they are not without risks. Due to the limited clinical studies on these compounds, their long-term effects and safety are not well-established. As such, users who choose to explore these SARMs should do so with caution and be well-informed of any potential risks involved.

In summary, S23 and RAD-140 are two potent SARMs that have shown potential in increasing muscle mass and strength. Both compounds selectively target androgen receptors, leading to their unique benefits and reduced side effects compared to traditional anabolic steroids. However, users should be aware of the limited research surrounding these compounds and exercise caution in their use.

Mechanism of Action

S23 and RAD-140 are both selective androgen receptor modulators (SARMs) that have gained popularity due to their potential to help build lean muscle mass and promote fat loss. They work by binding to androgen receptors in the body, specifically in muscle and bone cells. This regulated binding leads to selective anabolic effects, promoting muscle growth and bone health without causing many of the side effects typically associated with anabolic steroids.

S23 has been found to have a higher binding affinity for the androgen receptor compared to RAD-140. This higher affinity translates to potentially increased potency, making S23 more effective at lower doses. However, it might also give rise to a higher risk of side effects.

When it comes to protein synthesis, both S23 and RAD-140 play a significant role in enhancing this process within the muscle cells. Increased protein synthesis is key to building new muscle fibers and repairing damaged ones after workouts. This results in more significant muscle growth and strength improvements over time.

Additionally, both SARMs show a positive effect on growth hormone (GH) levels. GH facilitates muscle growth, fat metabolism, and tissue repair. By promoting GH release, S23 and RAD-140 may enhance muscle-building potential and stimulate increased fat burning.

  • Key points:
    • Both S23 and RAD-140 are selective androgen receptor modulators (SARMs)
    • Higher binding affinity of S23 to androgen receptors could increase both potency and risk of side effects
    • Both SARMs enhance protein synthesis, promoting muscle growth and repair
    • S23 and RAD-140 have the potential to stimulate the release of growth hormone (GH), supporting muscle development and fat loss

To sum up the mechanisms of action of S23 and RAD-140, their anabolic effects are achieved mainly by targeting androgen receptors, enhancing protein synthesis, and promoting GH release. The differentiation in their potency and, possibly, side effects is related to the differences in binding affinity to the androgen receptor.

Benefits of S23 and RAD-140 in Bodybuilding

S23 and RAD-140 are two potent selective androgen receptor modulators (SARMs) that have become popular in the bodybuilding community. These compounds offer a range of benefits for those looking to improve their physique. This section highlights some of the primary benefits of these SARMs in bodybuilding and how they differ in their effects.


S23 is known for its potential to increase lean muscle mass and enhance fat loss. It is particularly useful during a cutting cycle, where the goal is to reduce body fat while preserving muscle. Some key benefits of S23 in bodybuilding include:


RAD-140, also known as Testolone, is another popular SARM in the bodybuilding community. It exhibits a strong affinity for androgen receptors, leading to significant gains in muscle mass and strength. Some advantages of RAD-140 in bodybuilding include:

Although both S23 and RAD-140 share some common benefits, such as promoting lean muscle gains and supporting fat loss, they differ in certain aspects. S23 is more focused on cutting and vascularity, while RAD-140 is known for its strength and muscle-building capabilities. It is important to note that, unlike anabolic steroids, SARMs like S23 and RAD-140 have lower side-effect profiles, making them a more appealing alternative for bodybuilders. However, potential side effects such as acne and suppression of natural testosterone production could still occur, and users must be cautious of these risks when using these compounds in their fitness routines.

Potential Side Effects

Potential Side Effects of S23 and RAD-140

When considering the use of SARMs like S23 and RAD-140, it is crucial to understand their potential side effects. Both S23 and RAD-140 are selective androgen receptor modulators (SARMs) designed to provide anabolic benefits while minimizing undesirable side effects commonly associated with anabolic steroids.

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However, they do carry their own set of risks. This section will outline the potential side effects and risks for both of these compounds.


  • Testosterone Suppression: S23 has been known to cause significant suppression of natural testosterone production. This could lead to hormonal imbalances and require post-cycle therapy (PCT) to restore normal hormonal function.
  • Hair Loss: Some users have reported hair loss or male pattern baldness as a result of S23 usage, especially in those who are genetically predisposed.
  • Acne: Acne is another potential side effect linked to S23 use. Individual reactions will vary, and this side effect might be more common in those with a history of acne.
  • Safety: S23 is considered a more aggressive anabolic SARM than RAD-140, meaning it could come with an increased risk of side effects.


  • Testosterone Suppression: RAD-140 usage can also lead to testosterone suppression, albeit to a lesser degree than S23. However, PCT may still be necessary after using RAD-140.
  • Liver Toxicity: Although not as hepatotoxic as some anabolic steroids, RAD-140 has been associated with liver toxicity in some cases. Monitoring liver function throughout the cycle is advisable.
  • Mood Changes: Users of RAD-140 have reported different mood changes, with some experiencing mood elevation, while others might experience irritability or anxiety.
  • Safety: RAD-140 is considered a “safer” option compared to S23 due to its less aggressive nature, but it still carries potential risks.

It’s important to keep in mind that everyone’s response to these compounds may differ and consulting with a healthcare professional before using these substances is essential. While both S23 and RAD-140 have their associated side effects, the severity and occurrence of these effects might vary among individuals based on genetics and predispositions.

Dos and Don’ts for Usage

Dos and Don'ts for Usage of S23 and RAD-140

When comparing S23 and RAD-140, it’s crucial to understand the appropriate usage, dosages, and cycle lengths of each compound to ensure optimal results and minimize potential side effects. Here are several dos and don’ts to consider when using these selective androgen receptor modulators (SARMs).


S23: To achieve the desired effects, S23’s recommended dosage is between 10-30mg per day, typically divided into multiple doses due to its short half-life. It is crucial to start with a lower dose, especially for beginners, and gradually increase as your body adapts to the compound.

RAD-140: The typical dosage range for RAD-140 falls between 10-30mg per day, similar to S23. However, experienced users may opt to increase their dose based on their goals and body’s tolerance.

Cycle Length

Both S23 and RAD-140 are usually used in cycles ranging from 8 to 12 weeks, depending on the individual’s experience and goals. Keep in mind that longer cycles may increase the risk of adverse effects.

Post Cycle Therapy (PCT)

Following a cycle of either S23 or RAD-140, post cycle therapy is strongly recommended to help bring your body’s hormonal levels back to normal. PCT typically lasts between 4-6 weeks and should include over-the-counter products like Nolvadex or Clomid.

Test Base

When using S23, it is essential to incorporate a test base to avoid hormonal fluctuations, as this SARM may suppress testosterone production. On the other hand, testosterone base is usually not required when using RAD-140, as it has a much lower suppression rate.

Cutting and Stacking

Both S23 and RAD-140 can be used during cutting phases to maintain muscle mass while shedding body fat. However, they can also be stacked with other SARMs or supplements to amplify results. For example, S23 is often stacked with GW-501516 to promote fat loss, while RAD-140 might be combined with LGD-4033 for enhanced muscle growth.

In conclusion, proper usage, dosages, and cycle lengths are critical when considering S23 and RAD-140. Always listen to your body and adjust your approach accordingly, and consult a healthcare professional if you have concerns about incorporating these SARMs into your routine.

S23 and Rad-140 Research and Studies

S23 and Rad-140 Research and Studies

S23 and Rad-140 are selective androgen receptor modulators (SARMs) that have gained attention for their potential applications in fields such as anabolic therapy, and for their possible effects on muscle mass and bone density. Both of these compounds have been the subject of various scientific studies in order to better understand their mechanisms and effects.

RAD-140 is known for its ability to increase lean muscle mass and boost testosterone levels. Research has indicated that RAD-140 may have a positive impact on bone mineral density, making it a promising candidate for the treatment of osteoporosis and other bone-related disorders. Additionally, due to its selective actions, RAD-140 is believed to have reduced side effects when compared to traditional anabolic steroids.

Some of the key findings on RAD-140 include:

  • Increased lean muscle mass
  • Boosted testosterone levels
  • Potential improvement in bone mineral density
  • Reduced side effects compared to anabolic steroids

S23, on the other hand, has shown potential as a treatment for muscle wasting and bone loss, but may come with more significant side effects. In some studies, S23 has demonstrated the ability to increase bone density and muscle mass, while also displaying the capacity to reduce body fat. However, there have been reports of users experiencing shutdowns (a reduction in natural testosterone production) while using S23, indicating the need for caution and further research.

Some of the key findings on S23 include:

  • Potential to increase bone density
  • Muscle mass improvement
  • Reduction in body fat
  • Possible shutdowns and testosterone suppression

Both S23 and RAD-140 are currently on the World Anti-Doping Agency’s (WADA) list of prohibited substances, making them off-limits for professional athletes. It is also important to note that these SARMs are not yet approved medications and their long-term effects and safety profiles are not well established.

In terms of insulin, there is currently no substantial evidence in the available research that indicates any direct interaction or notable effects of S23 and RAD-140 on insulin regulation. However, as SARM research continues to evolve, potential impacts on insulin and other metabolic pathways may be uncovered in the future.

In summary, S23 and RAD-140 have both demonstrated potential benefits in the areas of muscle mass improvement and bone density enhancement, with RAD-140 appearing to have a more favorable side effect profile. As more research is conducted, the scientific community will continue to gain a better understanding of these compounds and their potential applications in various fields.

End User Opinions

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Bodybuilders and fitness enthusiasts have been found discussing and sharing their experiences with the use of S23 and RAD-140 on various online forums, including Reddit. These users have provided valuable insights into the efficacy and side effects of both compounds.

Some users on Reddit commented that, while S23 may be a more potent compound, it can come with more severe side effects than RAD-140. They reported experiencing shutdowns within a week of using S23 at a dose of 10mg per day. On the other hand, RAD-140 was mentioned to be a “safer” option, although some still experienced mild side effects when increasing the dosage beyond 10mg.

It is essential to note that individual responses to these compounds can vary significantly. Here is a brief summary of the reported experiences of some users:

  • S23: Stronger compound, but significant side effects, including shutdowns. PCT may be necessary.
  • RAD-140: Considered safer, with fewer side effects at lower dosages. Some users experienced negative effects with higher doses.

In another Reddit discussion, users compared their experiences with S23, RAD-140, and YK-11 (another SARM). They reported the following:

SARMEfficacySide Effects

End users frequently emphasized the importance of proper dosing and the necessity to use PCT (Post Cycle Therapy) to mitigate adverse side effects, especially when using S23.

Though these anecdotal experiences can give potential users an idea of what to expect, it is crucial to emphasize that personal outcomes may differ. As with any supplement or compound, it is recommended to consult a healthcare professional before starting a new regimen.

Comparisons – S23 vs Other SARMS

S23 and RAD-140 are both popular SARMs in the world of bodybuilding and fitness. In order to better understand how S23 compares to other SARMs, we’ll discuss its potency and unique characteristics in relation to Andarine (S4), Ostarine (MK-2866), YK-11, and Cardarine (GW-501516).

When comparing S23 to Andarine (S4), it’s important to note that S23 has a higher anabolic power. In a study, it was found that S23 has a strong affinity (1.7 nM) for androgen receptors, while Andarine (S4) has a lower affinity. This leads to S23 being more potent for muscle building purposes, although it also comes with stronger side effects.

Moving on to the comparison between S23 and Ostarine (MK-2866), the major difference lies in their target application. Ostarine is known for its mild anabolic properties and little to no side effects, making it a perfect choice for beginners and those looking for a safer option. On the other hand, S23 is more potent, thus delivering faster results in muscle growth, but with increased risk for side effects, making it a better fit for experienced users.

When we take a look at S23 and YK-11, it becomes clear that both compounds are potent muscle builders. While YK-11 may offer more gains with fewer side effects at lower dosages, S23 has more anabolic power. However, users have reported experiencing more side effects with S23 than with YK-11. It’s essential to consider individual tolerance and side effect management when choosing between these two SARMs.

Lastly, comparing S23 to Cardarine (GW-501516), it’s essential to understand that Cardarine is not a typical SARM. Whereas S23 primarily targets muscle growth, Cardarine is known for its role in enhancing endurance and fat burning. Many fitness enthusiasts stack Cardarine with other SARMs, including S23, to maximize their results.

In summary, when comparing S23 to other popular SARMs, it becomes apparent that it’s a highly potent muscle builder. However, its potency could translate to more side effects than some of its counterparts. It’s crucial for users to weigh the benefits and potential drawbacks when deciding to incorporate S23 into their regimen.

Frequently Asked Questions

What is the optimal dosage for S23 and RAD-140?

The optimal dosage for S23 can vary depending on factors such as goals, current body weight, and tolerance. Generally, users have reported positive results with a dosage range of 10mg to 30mg per day. On the other hand, RAD-140 is typically taken in lower dosages, with users often reporting effective results with a dosage range of 5mg to 20mg per day. It is always recommended to start at a lower dosage and gradually increase as necessary while monitoring your body’s reaction.

Can S23 and RAD-140 be effectively stacked?

Yes, S23 and RAD-140 can be effectively stacked for achieving specific goals, such as increased muscle mass and strength. However, it is essential to carefully plan and research the impact of stacking these two compounds together, as they may have synergistic effects. Always consult with a knowledgeable professional or do thorough research before implementing a SARMs stack.

What are the differences in results between S23 and RAD-140?

S23 and RAD-140 are both selective androgen receptor modulators (SARMs) with unique properties that lead to different results. S23 is known for its potential to increase muscle mass and promote fat loss, while also having strong effects on enhancing strength and muscle hardness. RAD-140 is well-regarded for its potential to assist in muscle growth, increase strength, and improve bone density.

Do S23 and RAD-140 cause hair loss or other side effects?

As with any compound, there is a potential for side effects when using S23 or RAD-140. The risk of hair loss may depend on individual predisposition and genetics. Other reported side effects for both compounds include suppression of natural testosterone production, sleep disturbances, and increased aggression. It is vital to monitor and manage these potential side effects carefully while using these compounds.

Is RAD-140 or S23 better for cutting cycles?

Both RAD-140 and S23 have been observed to produce positive results in cutting cycles. However, S23 is often favored for cutting due to its strong effects on muscle hardening and promoting fat loss. Ultimately, the choice between these two compounds for a cutting cycle will depend on individual preferences, goals, and tolerance to the specific compound.

What is the liver toxicity risk for S23 and RAD-140?

S23 and RAD-140 are non-steroidal SARMs, and therefore, they may have a lower liver toxicity risk compared to traditional anabolic steroids. However, it is still crucial to monitor liver health while using these compounds and implement proper liver support if necessary. Regular blood work and liver health checks are advised during and after any SARMs cycle to ensure safety.

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