RAD-140 (Testolone) Review: Ultimate Guide and Expert Analysis

Written by James C., M.S.(C), PT

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RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that has been gaining popularity among fitness enthusiasts and bodybuilders. Developed initially for medical purposes, this compound is designed to selectively bind to specific androgen receptors found in muscle tissue. With its potential muscle-building and performance-enhancing properties, RAD-140 is often considered an alternative to anabolic steroids while causing fewer side effects.

RAD-140 (Testolone) Review: Ultimate Guide and Expert Analysis

Researchers discovered that RAD-140 could potentially offer benefits such as increased muscle mass, strength, and fat loss. Given these potential advantages, it’s no surprise that it has piqued the interest of bodybuilding and fitness communities. However, it is essential to note that RAD-140 has not been approved by the FDA, and most of its claims and benefits are based on anecdotal evidence and recreational reports.

Key Takeaways

  • RAD-140, or Testolone, is a SARM with potential muscle-building and performance-enhancing properties
  • Developed for medical purposes, it selectively targets specific androgen receptors in muscle tissues
  • Benefits may include increased strength, muscle mass, and fat loss; however, it is not FDA approved and should be used with caution

What is RAD-140 (Testolone)

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) with promising effects on muscle growth and strength. As a non-steroidal compound, RAD-140 is designed to bind to the androgen receptor, leading to anabolic effects on muscle and bone tissue without the undesirable side effects often associated with steroids.

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Testolone was originally developed for the purpose of treating breast cancer and muscle wasting in postmenopausal women. Thanks to its ability to increase natural testosterone production and enhance lean body mass, RAD-140 has become popular among bodybuilders and strength athletes.

SARMs, including RAD-140, come with several benefits:

  • Highly selective binding to androgen receptors in muscle and bone tissue
  • Minimal side effects compared to anabolic steroids
  • Potential for increased muscle mass and bone density

When using RAD-140, users have reported noticeable gains in strength and muscle mass, along with a reduction in body fat. The compound is thought to have a high affinity for muscle receptors and bone tissues, making it an ideal choice for those looking to build muscle quickly and improve overall bone health.

Please note that while studies on RAD-140 have shown potential benefits, it is essential to consult a healthcare professional before incorporating any SARMs, including Testolone, into your training regimen. Additionally, long-term use and safety warrant further research, so exercise caution and stay informed about the latest developments in this area.

History and Development

history and development of RAD-140 testolone

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that was developed by Radius Health Inc. This compound was initially synthesized to target the androgen receptors in muscle and bone tissue, leading to increased muscle mass and strength without many of the adverse effects associated with traditional anabolic steroids.

The research and development of RAD-140 commenced in the early 2010s. The objective was to come up with a safer alternative to hormone replacement therapy (HRT) for muscle wasting diseases and osteoporosis. The benefits of typical anabolic steroids were well-known, but their side effects, such as liver damage, cardiovascular risks, and reproductive organ issues, were significant concerns.

Due to its potential to enhance athletic performance, RAD-140 is now part of the World Anti-Doping Agency’s (WADA) list of prohibited substances. This means it is banned for use in any competitive sports as it could provide an unfair advantage to those who use it.

During the development of RAD-140, researchers discovered that it exhibited a high degree of selectivity in binding to androgen receptors in muscle and bone tissues, while avoiding undesirable side effects on reproductive organs and other tissues. This property makes it a more appealing option for those seeking the advantages of anabolic steroids without the corresponding drawbacks.

In recent years, the interest in RAD-140 has also expanded to exploring its potential therapeutic applications, such as combating muscle wasting in conditions like cancer and promoting the recovery of neuromuscular function after injury.

In summary, the development of RAD-140 (Testolone) by Radius Health Inc. marked a significant step forward in the field of selective androgen receptor modulators. Its potential therapeutic uses, coupled with the reduced risk of adverse effects, make it a noteworthy compound in the ongoing quest to develop safe and effective muscle-building and performance-enhancing solutions.

Mechanism of Action

RAD-140 (Testolone) is a selective androgen receptor modulator (SARM) known for its muscle-building and strength-enhancing effects. The compound was discovered and formulated by the US biotechnology company Radius Health in 2010. SARMs, such as RAD-140, exhibit selective tissue actions, which allows them to produce anabolic effects on muscle and bone tissues without impacting other androgen-affected organs like the prostate and seminal vesicles.

SARMs like RAD-140 work by binding to androgen receptors, which are proteins primarily found in male reproductive tissues, muscles, and bones. These receptors play a crucial role in the development and maintenance of masculine characteristics, such as increasing muscle mass and bone density.

The mechanism of action of RAD-140 can be explained through its tissue-selectivity. While it binds with high affinity to androgen receptors, it displays agonistic effects in anabolic target tissues such as skeletal muscles and antagonistic or weak agonistic effects in reproductive organs. This tissue selectivity addresses many of the side effects commonly associated with conventional anabolic steroids.

The following list highlights some of the major benefits associated with the use of RAD-140:

  • Muscle growth: RAD-140 helps promote muscle tissue growth and lean mass gains, making it highly desirable for bodybuilders and fitness enthusiasts.
  • Strength increase: Users often experience significant increases in strength and lifting capabilities during their RAD-140 cycles.
  • Bone density improvement: Due to its affinity for androgen receptors in bones, RAD-140 may help improve bone density, potentially benefiting individuals with osteoporosis or related conditions.

In summary, RAD-140’s mechanism of action revolves around its selective and tissue-specific binding to androgen receptors. This enables anabolic effects on muscles and bones without many of the side effects typically associated with traditional anabolic steroids. This unique property has attracted significant attention in the fields of fitness, bodybuilding, and medical research for its potential therapeutic applications.

Potential Benefits

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that has gained popularity for its potential benefits in boosting physical performance and enhancing muscular development. In this section, we will discuss some of the potential benefits associated with the use of RAD-140.

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Strength and Muscle Mass: One of the primary benefits of RAD-140 is its ability to significantly increase strength and muscle mass. By selectively binding to the androgen receptors, RAD-140 promotes anabolic activity, leading to increased muscle growth and lean muscle mass. Numerous users have reported significant strength gains and muscle gains after using RAD-140.

Energy and Endurance: Another advantage of RAD-140 is its positive impact on energy levels and endurance. As a performance-enhancing supplement, it supports the body’s ability to withstand more intense and longer workouts, resulting in greater stamina and muscular strength.

Fat Loss: The use of RAD-140 can also contribute to fat loss. It has been reported to enhance the body’s fat-burning capacity, making it an ideal supplement for those looking to improve their body composition and achieve a more chiseled appearance.

Anabolic Effects: Due to its selective nature, RAD-140 replicates the anabolic effects of steroids without causing undesirable side effects. This makes it a safer alternative for individuals who wish to improve their performance and muscle development without resorting to harmful anabolic steroids.

In summary, RAD-140 has shown promise in various aspects of physical performance enhancement, such as strength, muscle mass, energy, endurance, anabolic activity, and fat loss. It has become a popular option for those looking to boost their athletic performance and achieve their fitness goals. However, as with any supplement, it’s important to use caution and consult a medical professional before trying RAD-140 to ensure it’s suitable for your individual needs.

Usage and Dosage

usage and dosage of RAD-140 testolone

RAD-140, also known as Testolone, has gained popularity among bodybuilders and fitness enthusiasts for its reported benefits on muscle mass, strength, and fat loss. In this section, we will discuss the proper usage and dosage of RAD-140 to help you make an informed decision.

When it comes to the dosage of RAD-140, a common recommendation is to take between 5 and 20 mg per day. The lower end (5 mg) of this range is considered a conservative dose, especially for beginners or those who are more sensitive to the compound. On the other hand, experienced users may opt for higher doses, within the 10-20 mg range, to maximize its potential.

It is important to note that RAD-140 is quite potent even in small doses. Therefore, it is advisable to start with a low dosage and gradually increase it based on individual tolerance and desired results.

A typical cycle of RAD-140 generally lasts for 8 to 12 weeks. It is not recommended to exceed this duration, as the risk of adverse effects may increase with prolonged use. To ensure that the body’s hormonal levels return to their natural state following a cycle, a post-cycle therapy (PCT) may be necessary.

In some cases, users may choose to stack RAD-140 with other selective androgen receptor modulators (SARMs) or supplements to enhance its benefits. Common stacks include:

  • RAD-140 with Ostarine (MK-2866): for lean muscle mass and strength gains
  • RAD-140 with Ligandrol (LGD-4033): for increased muscle mass and bulking
  • RAD-140 with Cardarine (GW-501516): for improved endurance and fat loss

When incorporating a stack, it is crucial to adjust the individual dosages accordingly and closely monitor the body’s reaction to avoid overstimulation.

In conclusion, the proper usage and dosage of RAD-140 play a critical role in obtaining the desired results while minimizing the risk of adverse effects. By starting with a low dose, adhering to a reasonable cycle duration, and considering post-cycle therapy, users can make the most of this potent SARM.

Common Stacking Options

RAD-140 Testolone Stacking Options

RAD-140 (Testolone) is a popular SARM (Selective Androgen Receptor Modulator) known for its anabolic effects and ability to enhance muscle growth and strength. When it comes to stacking Testolone with other SARMs or compounds, there are a few widely-used combinations that have been reported to provide synergistic benefits. Here are some common options to consider if you’re interested in stacking RAD-140.

  1. RAD-140 and LGD-4033 (Ligandrol): This stack combines two powerful SARMs to potentially boost muscle mass and strength. RAD-140 is known for its anabolic effects, while LGD-4033 is recognized for its ability to increase lean muscle mass. However, be cautious with stacking these two together as it has been suggested some users experienced higher levels of testosterone suppression and impact on organs compared to using either compound alone.
  2. RAD-140 and GW-501516 (Cardarine): Testolone and Cardarine stack well together for individuals aiming to boost their muscular endurance and stamina, as well as those who want to shed body fat effectively. RAD-140 provides muscle growth benefits and Cardarine helps improve cardiovascular endurance, making it an appealing tandem for athletes worried about their aerobic capacity.
  3. RAD-140 and MK-2866 (Ostarine): This combination could be advantageous for those looking to improve muscle mass while simultaneously supporting joint health. Ostarine is known primarily for its capacity to promote muscle growth and support joint health, making it an ideal partner for RAD-140’s anabolic properties.
  4. RAD-140 and MK-677 (Ibutamoren): This stacking option has the potential to encourage muscle growth and recovery, as well as facilitate better sleep quality. RAD-140’s muscle-building effects in conjunction with MK-677’s ability to increase growth hormone levels may lead to better muscle development and overall recovery.
  5. RAD-140 and S23: When stacked together, RAD-140 and S23 can potentially deliver considerable muscle growth and strength benefits. S23 is an investigational SARM that has shown to promote lean muscle mass and increase bone mineral density. However, due to its potency and lacking research data, it is advised to approach this stack with caution, especially for beginners.

It is essential to note that before considering any stack, research the compounds and potential side effects adequately to make an informed decision. Each individual responds differently, so it’s crucial to begin with lower dosages and monitor your body’s reaction before increasing the dose or duration of your cycle. Always prioritize safety and long-term health over short-term gains.

Side Effects and Risks

RAD-140 testolone side effects and risks

While RAD-140 (Testolone) has been shown to have potential anabolic effects on muscle tissue without many of the negative impacts on reproductive organs, it’s important to be aware of the potential side effects and risks associated with its use.

Testosterone Suppression: RAD-140 may lead to temporary suppression of natural testosterone production. It is important to monitor hormone levels and consider post-cycle therapy to help restore natural testosterone levels after using RAD-140.

Acne and Hair Loss: Some users have reported experiencing acne and hair loss, although these side effects seem to be relatively rare. It is essential to keep an eye out for these symptoms and discontinue use if they occur.

Nausea and Vomiting: In some cases, RAD-140 users may experience gastrointestinal symptoms such as nausea and vomiting. These side effects are typically mild and resolve over time, but it is crucial to stay hydrated and monitor these symptoms as needed.

Gynecomastia: There is a possibility of developing gynecomastia, the enlargement of breast tissue in males, while using RAD-140. This potential risk can usually be managed by supplementing with an aromatase inhibitor during the cycle if needed, but you should be prepared if this side effect occurs.

It’s worth noting that RAD-140 is still undergoing clinical research, so additional side effects and risks may emerge as more studies are conducted. Users should approach the use of RAD-140 with caution, and always consult a medical professional before adding the compound to their fitness routine.

Post Cycle Therapy

Post Cycle Therapy for RAD-140 Testolone PCT

An essential aspect of using RAD-140 (Testolone) is the implementation of Post Cycle Therapy (PCT). PCT helps to restore your body’s natural hormone balance after completing a cycle of Testolone, preventing any potential undesirable side effects. In this section, we will discuss the importance and possible options for PCT.

After completing a cycle of Testolone, your body may experience a reduction in the production of natural testosterone. This is due to the suppression caused by RAD-140, as it binds to androgen receptors and acts like testosterone, leading to a temporary decrease in the body’s testosterone levels.

To counteract this testosterone suppression, PCT is necessary. The primary objective of PCT is to stimulate your body to regain its natural testosterone production. Two common PCT options for RAD-140 include:

  • Clomid (Clomiphene Citrate): A selective estrogen receptor modulator (SERM) often used in PCT. Clomid stimulates the pituitary gland to release hormones necessary for testosterone production. The typical Clomid dosage ranges from 50-100 mg per day for 4-6 weeks following a Testolone cycle.
  • Nolvadex (Tamoxifen Citrate): Another SERM, similar to Clomid, utilized in PCT. Nolvadex also supports the restoration of natural testosterone production by stimulating the pituitary gland. The standard Nolvadex dosage ranges from 20-40 mg per day for 4-6 weeks post-cycle.

An example of a typical PCT plan for RAD-140, lasting 4 weeks, could be:

WeekClomid (daily)Nolvadex (daily)
150 mg20 mg
250 mg20 mg
325 mg10 mg
425 mg10 mg

In conclusion, conducting a proper PCT following a RAD-140 (Testolone) cycle is imperative to ensure a healthy hormonal balance and minimize potential side effects. The inclusion of either Clomid or Nolvadex in your PCT routine can significantly aid in the restoration of natural testosterone production. Always consult with a healthcare professional before starting a PCT regimen to guarantee its effectiveness and safety.

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that has gained popularity for its potential in boosting strength, muscle mass, and reducing body fat. As a relatively new compound, the legal status of this SARM may be unclear for many individuals.

In the United States, RAD-140 is not approved by the Food and Drug Administration (FDA) for human use. This means that it is not allowed to be sold as a dietary supplement or a prescription medication. However, it is legal to purchase and possess RAD-140 for research purposes. While this allows for a limited availability, it is important to note that using Testolone for personal use can be risky as it is not regulated by the FDA.

In the European Union, SARMs including RAD-140 have been classified as non-approved substances. This means that they are not legally available for sale or consumption within the European Union member states. However, possession and use for individual research purposes may not be considered a legal issue, depending on the country’s specific rules and regulations.

The legal status of RAD-140 varies between countries worldwide. Some countries have specific restrictions on the importation, sale, and use of Testolone, while others may not have any particular regulations related to this SARM. It is essential for individuals to verify their country’s legal guidelines regarding RAD-140 before obtaining or using the substance.

To summarize, the legality of Testolone varies worldwide, with a general trend of its non-approval for human consumption. Researchers and individuals interested in personal use should thoroughly examine their country’s regulations before obtaining RAD-140.


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In summary, RAD-140 (Testolone) is a non-steroidal SARM that aims to replicate the anabolic effects of steroids by binding to the androgen receptor. It has gained popularity amongst fitness enthusiasts and bodybuilders for its potential benefits in muscle growth, fat loss, and strength enhancement.

Based on customer reviews and anecdotal evidence, many users have reported positive effects from the use of RAD-140, such as increased muscle mass, enhanced performance, and a more shredded appearance. However, it’s essential to understand that individual results may vary, and one should always consider personal goals and safety.

Here are some key points to note about RAD-140 (Testolone):

  • Non-steroidal SARM
  • Potential benefits in muscle growth, fat loss, and strength enhancement
  • Positive customer reviews and anecdotal evidence

As with any supplement, it’s crucial to consult a healthcare professional before starting a RAD-140 regimen to ensure its suitability for your individual needs and to avoid possible side effects. Furthermore, it is recommended to conduct thorough research and select reputable sources when purchasing RAD-140 to ensure product quality and safety.

Frequently Asked Questions

What are the common side effects of RAD-140?

While RAD-140 is considered to have fewer side effects than anabolic steroids, users may still experience some side effects. These can include suppressed testosterone production, increased aggression, changes in mood, and insomnia. It is important to keep in mind that individual experiences may vary and not everyone will experience these side effects.

The recommended dosage for RAD-140 varies depending on individual goals and experience levels. A typical dosage range is between 5 mg to 20 mg per day. It is advised to start with a lower dosage and gradually increase based on individual tolerance and results.

How long does it take for RAD-140 to show results?

The time it takes for RAD-140 to show results can vary depending on factors such as individual response, dosage, and training regimen. However, users often report noticing an increase in strength and muscle mass within the first few weeks of using RAD-140. For optimal results, it is generally recommended to use RAD-140 for a period of 8 to 12 weeks.

Is post cycle therapy necessary after using RAD-140?

Post cycle therapy (PCT) is recommended after using RAD-140 to help restore natural testosterone production. Due to the suppressive nature of RAD-140, a PCT protocol should be followed to minimize potential side effects and ensure a proper hormonal balance is achieved once the cycle is completed.

Can RAD-140 be stacked with testosterone?

RAD-140 can be stacked with testosterone or other compounds to achieve specific goals or enhance results. However, caution and proper research should be undertaken when stacking RAD-140 with other substances, as this may increase the risk of potential side effects. It is crucial to carefully consider one’s goals, experience, and tolerance before initiating a stack.

Is RAD-140 harmful to the liver?

There is limited research on the potential liver toxicity of RAD-140. Based on the available information, it is not considered to be harmful to the liver. Nonetheless, it is always a good practice to monitor liver health through periodic blood tests, especially when using any supplement, medication, or performance-enhancing compound.

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