MK-677 (Ibutamoren) Review: Discover the Pros and Cons

Written by James C., M.S.(C), PT

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Welcome to my Ibutamoren review. It’s known as MK-677, and it is a popular and intriguing compound that has caught the attention of individuals looking to improve their fitness levels, body composition, and overall well-being. This compound is not a selective androgen receptor modulator (SARM), but rather a growth hormone secretagogue that mimics the action of ghrelin, a hormone that stimulates the production of growth hormone (GH) in the body. GH plays a crucial role in muscle growth, fat loss, and a myriad of other metabolic processes that contribute to an individual’s overall health.

MK-677 (Ibutamoren) Review: In-Depth Analysis and User Experience

Ibutamoren has been the subject of various clinical trials and research studies, with findings suggesting that the compound may elicit numerous health benefits. Some potential benefits include increased muscle mass, reduced body fat, enhanced recovery, and improved sleep quality. However, it’s important to approach the use of MK-677 with caution and to be well-informed about dosage recommendations and possible side effects, as well as its mechanism of action and classification.

Key Takeaways

  • MK-677 (Ibutamoren) is a growth hormone secretagogue, not a SARM, that mimics ghrelin and stimulates GH production.
  • Potential benefits include increased muscle mass, reduced body fat, enhanced recovery, and improved sleep quality.
  • It’s crucial to be cautious and informed about dosage recommendations, possible side effects, and the compound’s mechanism of action.

Understanding Ibutamoren (MK-677)

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Ibutamoren, also known as MK-677 and MK-0677, is an orally active growth hormone secretagogue. It is a potent, selective, and non-peptide agonist of the ghrelin receptor. By mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin, Ibutamoren helps to increase levels of growth hormone (HGH) and insulin-like growth factor-1 (IGF-1) in the body.

Ghrelin is a hormone produced by the stomach and plays a crucial role in controlling appetite, energy balance, and the release of growth hormone. Ibutamoren, as a ghrelin receptor agonist, works by binding to and activating ghrelin receptors. This activation stimulates the release of HGH from somatotroph cells in the pituitary gland. Also, MK-677 inhibits somatostatin, a hormone responsible for blocking the release of growth hormone.

Some of the potential benefits of Ibutamoren may include:

  • Increased muscle mass
  • Enhanced bone density
  • Improved sleep quality
  • Boosted energy levels
  • Faster recovery of damaged tissues

It is essential to note that while MK-677 shows promising results, it is not a SARM (selective androgen receptor modulator) like many people mistakenly believe. It is actually a growth hormone secretagogue, which promotes the release of GH through a different mechanism from SARMs.

Ibutamoren (MK-677) is often used in conjunction with other fitness and performance-enhancing supplements. However, the compound is still under research, and its long-term safety and efficacy are yet to be fully determined. Therefore, it is crucial to approach Ibutamoren with caution and use it under the guidance of a knowledgeable professional.

In conclusion, Ibutamoren (MK-677) has shown promising potential in boosting growth hormone levels and improving various health aspects. As a ghrelin receptor agonist, it acts differently from SARMs and other conventional performance enhancers. While it may offer notable benefits, its long-term safety and effectiveness remain uncertain, and users should exercise caution when considering it for supplementation.

Classification of MK-677 and Mechanism of Action

Classification of MK-677 and Mechanism of Action

MK-677, also known as Ibutamoren, is a non-peptide, orally-active compound that falls under the category of growth hormone secretagogues (GHS). Despite being commonly associated with selective androgen receptor modulators (SARMs), Ibutamoren is not a SARM itself. It is important to differentiate MK-677 from SARMs, as their mechanisms of action are quite distinct.

Ibutamoren primarily functions as a ghrelin receptor agonist, which means that it stimulates the same receptor that ghrelin, an endogenous hormone, does. By binding to the ghrelin receptor, MK-677 promotes the secretion of growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). This is how Ibutamoren functions differently from SARMs, as it is mimicking the actions of ghrelin instead of directly targeting androgen receptors.

Below is a brief overview of MK-677’s mechanism of action compared to that of SARMs:

Compound CategoryTarget ReceptorsPrimary Effects
MK-677 (Ibutamoren)Ghrelin Receptor (GHSR)Secretion of growth hormone and IGF-1
SARMsSelective Androgen ReceptorStimulate muscle growth and other androgenic effects

One interesting aspect of Ibutamoren is that it selectively stimulates the release of GH and IGF-1 without significantly increasing cortisol levels. Cortisol is a stress hormone that can lead to negative health effects if elevated for extended periods. This selectivity makes MK-677 potentially useful for various therapeutic applications, such as treating growth hormone deficiency and age-related muscle wasting.

In summary, MK-677 (Ibutamoren) is designed to imitate the hormone ghrelin’s action, targeting the ghrelin receptor to enhance growth hormone secretion and IGF-1 production. Its mechanism of action is distinct from selective androgen receptor modulators (SARMs), which specifically act on androgen receptors to exert their effects.

Dosage Recommendations

MK-677, also known as Ibutamoren, is a potent compound that has become popular in the anti-aging and fitness communities. To ensure its effectiveness and reduce the risk of side effects, it is crucial to follow proper dosage guidelines. This section will provide dosage recommendations for those looking to try MK-677.

Beginner Dosage: For those who are new to MK-677, starting with a lower dosage is advised. Researchers have found that as little as 10mg per day can have positive effects on growth hormone levels1. Therefore, beginning with a 10mg daily dose is a reasonable choice.

Intermediate Dosage: As an individual becomes more accustomed to MK-677, they may consider increasing their daily dose. A commonly recommended intermediate dosage is 25mg per day. This dose has been shown to yield significant improvements in muscle mass, sleep quality, and energy levels.

Advanced Dosage: Experienced users who have assessed their tolerance to MK-677 might consider a higher dosage to maximize the benefits. However, it is important to note that the optimal dosage will depend on factors such as body weight, overall health, and personal goals. The maximum dosage typically suggested is 50mg per day. Beyond this point, the risk of side effects and diminishing returns may outweigh the potential benefits.

Regarding the cycle and cycle length, it is recommended to cycle MK-677 for consistency in achieving its benefits. A typical cycle lasts 8 to 12 weeks, followed by a 4-week break to allow the body to readjust and maintain its natural balance.

In summary, it is essential to start with a lower dosage of MK-677 and gradually adjust based on individual experiences and goals. Proper dosage guidelines, combined with careful cycling, can maximize the potential benefits of MK-677 while minimizing the risk of side effects.

Benefits of Ibutamoren (MK-677)

Ibutamoren, commonly known as MK-677, has become popular among bodybuilders, athletes, and fitness enthusiasts for its numerous benefits. In this section, we will discuss the advantages of using Ibutamoren, focusing on the following aspects: muscle mass, sleep quality, bone density, appetite, energy levels, hormones, and recovery.

First and foremost, MK-677 has a positive impact on muscle growth. It acts as a growth hormone secretagogue, stimulating the release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). These hormones play a crucial role in promoting muscle mass, strength, and recovery. As a result, users can experience significant gains in lean body mass and improved muscle-building potential.

In addition to muscle growth, MK-677 is known for its ability to improve sleep quality. Improved sleep is essential for muscle recovery, hormonal balance, and overall well-being. By increasing the release of growth hormone, Ibutamoren can effectively enhance sleep duration and quality, allowing individuals to wake up feeling refreshed and energized.

Another key benefit of Ibutamoren is its effect on bone density. The increase in growth hormone and IGF-1 levels contributes to stronger bones by promoting bone mineralization and turnover. This can be especially beneficial for older adults, as a decline in bone density is common with age, leading to a higher risk of fractures.

Furthermore, MK-677 can help with appetite regulation. The compound stimulates the production of ghrelin, a hunger hormone that increases appetite. While this might be a concern for some, it can be advantageous for individuals looking to bulk up and increase their caloric intake.

MK-677 also provides a noticeable boost in energy levels. Increased energy can translate into more productive workouts, allowing users to push harder and progress more quickly in their fitness journeys. This, combined with the compound’s ability to enhance muscle growth and strength, makes it an appealing supplement for bodybuilders and athletes alike.

Another advantage of Ibutamoren is its impact on hormonal balance. By increasing the production of growth hormone and IGF-1, it promotes a more favorable hormone profile for muscle growth, recovery, and overall health. Moreover, the compound does not negatively affect testosterone levels, an important consideration for male users.

Finally, MK-677 plays a vital role in accelerating recovery. The improved sleep quality and increased hormonal output contribute to enhanced muscle repair and regeneration. This can help speed up the recovery process, allowing users to return to their workouts sooner and with less soreness.

In conclusion, Ibutamoren offers a wide range of benefits for individuals seeking to improve muscle mass, strength, sleep quality, bone density, appetite, energy levels, hormonal balance, and recovery. Its unique mechanism of action and appealing attributes make it a popular choice for those looking to optimize their physical performance and well-being.

How Ibutamoren Effects Growth Hormone and IGF-1

How Ibutamoren Effects Growth Hormone and IGF-1

Ibutamoren, also known as MK-677, is a growth hormone secretagogue that stimulates the production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in the body. It is not a selective androgen receptor modulator (SARM) as commonly misunderstood, but rather functions through a distinct mechanism.

The primary mechanism of action for Ibutamoren involves interacting with a specific receptor in the pituitary gland and hypothalamus. This interaction stimulates a release of GH, leading to increased GH and IGF-1 serum levels. Unlike injectable growth hormones, Ibutamoren does not drastically elevate GH and IGF-1 levels beyond the normal range, minimizing the risk of adverse side effects like cancer.

To better understand the effects of Ibutamoren on GH and IGF-1 levels, let’s look at some factors:

  1. Half-life: Ibutamoren has a longer half-life than other growth hormone secretagogues, which allows for once-daily oral administration.
  2. Efficacy: Boosting GH and IGF-1 levels with Ibutamoren has been shown to significantly improve lean muscle mass, strength, and endurance.
  3. Safety: When compared to injectable human growth hormone (HGH) treatments, Ibutamoren has fewer side effects, and fewer contraindications for use.
  4. Targeted approach: Ibutamoren is effective in treating specific GH deficiencies without adversely affecting overall hormonal balance.

Though Ibutamoren does not directly affect insulin levels, it is essential to monitor any potential changes, especially for individuals with pre-existing diabetes or insulin resistance. Regular blood tests and medical supervision are necessary to ensure the safe and effective use of Ibutamoren for increasing GH and IGF-1 levels.

In summary, Ibutamoren is a potent growth hormone secretagogue that stimulates the production of GH and IGF-1 in the body, primarily by interacting with a specific receptor in the pituitary gland and hypothalamus. The safe and targeted approach of Ibutamoren makes it a promising alternative to traditional HGH treatments for those with growth hormone deficiencies.

Side Effects and Safety Concerns

Side Effects and Safety Concerns

MK-677 (Ibutamoren) has been known to exhibit certain side effects and safety concerns that users should be aware of. To provide a clear understanding, these effects are outlined below.

One of the common side effects is water retention. Users might experience an increase in water weight and bloating during the use of the compound. This can be mitigated through proper diet and exercise.

MK-677 is also associated with an increase in hunger hormone levels, which may lead to an increase in appetite and calorie consumption. It’s essential to maintain a balanced diet to avoid excessive weight gain during the cycle.

Another reported side effect is lethargy. Some users might feel more tired and sluggish than usual. This can be managed by adjusting the dosage or timing of administration.

Additionally, users have reported occasional headaches while using MK-677. It’s essential to stay hydrated and pay attention to any other factors that might contribute to headache development.

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In some cases, MK-677 has been linked to increased blood pressure. Users with pre-existing hypertension should closely monitor their blood pressure throughout the cycle.

There are also concerns regarding reduced insulin sensitivity. Users with a history of diabetes or metabolic syndromes should exercise caution before starting MK-677.

Cortisol levels can also be affected by the use of the compound. Since cortisol is a stress hormone, increased levels may lead to mood swings, fatigue, and sleep disturbances.

While MK-677 is taken orally, there are no concerns about injections or their associated complications, such as infections or scarring.

In terms of post-cycle therapy (PCT), there is limited information available, but some users have reported undergoing PCT due to concerns about potential hormonal imbalances.

With these potential side effects in mind, it’s crucial for users to consult a healthcare professional before starting MK-677 and to monitor their body’s response throughout the cycle. Proper dosage, diet, and exercise can help minimize these effects and ensure a safer experience with the compound.

Interactions with Steroids and Anabolic Steroids

Interactions with Steroids and Anabolic Steroids

MK-677, also known as Ibutamoren or Nutrobal, is a potent growth hormone secretagogue that stimulates the secretion of growth hormones. Though it is not a steroid, it can be used in conjunction with anabolic steroids and selective androgen receptor modulators (SARMs) to enhance muscle growth, endurance, and recovery.

When combined with anabolic steroids, MK-677 works synergistically to improve muscle growth and recovery. Anabolic steroids, such as testosterone, promote anabolism, the process in which the body builds muscles. However, they also increase the likelihood of experiencing side effects due to their hormonal nature. Adding MK-677 to a steroid cycle may help augment the anabolic effects while lessening the negative impact on the user’s hormone levels.

Here are some key benefits to using MK-677 alongside steroids and anabolic steroids:

  • Enhanced muscle growth: Combining MK-677 with anabolic steroids enhances the muscle growth potential of the stack, as both compounds work together to increase protein synthesis and stimulate muscle growth.
  • Improved endurance: The increased growth hormone release from MK-677 helps improve endurance, allowing users to perform better during intense training sessions.
  • Faster recovery: Growth hormone plays a crucial role in repairing damaged cells and tissues. Combining MK-677 with steroids ensures faster recovery and allows for more frequent and intense training sessions.

It’s essential to consider the dosage while using MK-677 with steroids, as each compound’s potency will affect the stack’s overall results. Typical dosages for MK-677 range from 10-25mg per day, while anabolic steroid dosages will vary depending on the specific compound used.

Furthermore, it’s crucial to manage the duration of these combined cycles. Since MK-677 does not have significant hormonal side effects, it can be used for more extended periods compared to conventional anabolic steroids. However, users should closely monitor their body’s reactions and adjust the duration or dosage accordingly.

In conclusion, MK-677 can be a valuable addition to a steroid or anabolic steroid cycle due to its ability to enhance muscle growth, endurance, and recovery. However, users should carefully consider the dosage and duration to optimize results while minimizing the potential for side effects.

The Role of Ibutamoren in Bodybuilding and Fitness

The Role of Ibutamoren in Bodybuilding and Fitness

Ibutamoren (MK-677) is a non-peptide agonist of ghrelin receptors and a growth hormone secretagogue, which means it stimulates the release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Due to its GH stimulating effects, it has been increasingly popular in the bodybuilding and fitness community.

One of the major advantages of Ibutamoren in bodybuilding is its ability to promote muscle growth and prevent muscle wasting. By increasing GH and IGF-1 levels, it helps to increase muscle mass without causing the negative side effects observed with the use of synthetic GH. It is particularly beneficial for individuals who are on a cutting phase, as it maintains muscle mass while promoting lipolysis, which refers to the breakdown of fats, resulting in the desired definition.

In the fitness world, it’s quite common to stack Ibutamoren with other substances, such as selective androgen receptor modulators (SARMs) or cardarine, which are known to improve endurance and speed up fat loss. Stacking can provide synergistic benefits, thus maximizing the potential gains and aiding in a more effective cutting or bulking cycle.

Besides its muscle-building properties, Ibutamoren also has a positive impact on several other aspects of health. For instance, it improves skin health by reducing wrinkles and fine lines, thanks to the increased production of GH. Moreover, some users have reported better sleep quality due to the increased production of GH during deep sleep, which is crucial for muscle repair and overall well-being.

In summary, Ibutamoren plays a significant role in bodybuilding and fitness by promoting muscle growth, preventing muscle wasting, and assisting in cutting phases. When stacked with other complementary substances, it can further enhance its benefits, making it a valuable addition to any fitness regimen.

Ibutamoren and Metabolic Functions

Ibutamoren (MK-677) is a growth hormone secretagogue, known to stimulate the production of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). It may have significant effects on various metabolic functions in the body, such as glucose metabolism, insulin sensitivity, and lipid metabolism.

One of the primary functions of GH and IGF-1 is regulating blood glucose levels, thereby affecting carbohydrate metabolism. In normal physiological conditions, these hormones help maintain blood sugar levels within an optimal range. Ibutamoren, by increasing the secretion of GH and IGF-1, could potentially improve glucose metabolism and maintain blood sugar within a healthy range.

Implications in diabetes: Ibutamoren might offer some benefits in individuals with diabetes or those at risk of developing the condition. By promoting the production of GH and IGF-1, it could potentially enhance insulin sensitivity and reduce insulin resistance, a primary concern in individuals with type 2 diabetes. However, more clinical trials are needed to ascertain its safety and efficacy in diabetic patients.

Regarding lipid metabolism, Ibutamoren could have a positive impact on fat mobilization and oxidation. By stimulating GH and IGF-1 secretion, it may promote lipolysis – the breakdown of fat into free fatty acids to be used as energy. Consequently, this could lead to a reduction in fat storage and potentially improve body composition.

In summary:

  • Ibutamoren stimulates the production of GH and IGF-1, affecting various metabolic functions.
  • It may help regulate blood glucose levels and improve glucose metabolism.
  • Potential benefits for individuals with diabetes or at risk of developing the condition.
  • Could impact lipid metabolism, promoting lipolysis and reducing fat storage.

It is crucial to note that although Ibutamoren holds promise for its potential metabolic effects, more research is needed to confirm these benefits and determine its safety profile. As always, it is essential to consult with a healthcare professional before considering the use of any supplement or medication.

Clinical Trials and Research Findings

Ibutamoren (MK-677) is an orally-active growth hormone secretagogue and ghrelin receptor agonist that has been explored in numerous clinical trials and studies for its potential therapeutic benefits. It stimulates the pituitary gland to produce and release growth hormone (GH) and insulin-like growth factor 1 (IGF-1) without significantly affecting cortisol levels1. Researchers have been particularly interested in its effects on muscle mass, bone density, and overall well-being.

In a 2-month trial involving 24 obese males, ibutamoren successfully increased GH and IGF-1 levels, showcasing its potential in stimulating growth hormone production2. Another study demonstrated that ibutamoren treatment could sustain increased GH and IGF-1 levels for up to 2 years, further supporting its potency as a growth hormone stimulator3.

Due to its impact on GH and IGF-1 secretion, ibutamoren has been investigated for its potential in improving body composition, bone density, and muscle mass. While existing data from clinical trials support ibutamoren’s ability to positively influence these aspects, more extensive studies are still needed to validate its long-term safety and effectiveness3.

Several studies have also sought to evaluate ibutamoren’s potential anti-aging properties, as IGF-1 levels are known to decrease as people age. One particular study, however, found that ibutamoren had no significant clinical effect on Alzheimer’s disease progression, suggesting that its potential in treating age-related cognitive decline may be limited4.

In terms of height, while some researchers have hypothesized that ibutamoren may influence linear growth due to its impact on growth hormone secretion, no concrete evidence or studies have yet confirmed this claim. Further research is needed to explore the extent of ibutamoren’s effects on height.

Overall, the clinical trials and research findings on ibutamoren (MK-677) highlight its potential benefits in various health-related aspects, such as muscle mass, bone density, and growth hormone production. However, further studies are essential to better understand its long-term safety, effectiveness, and possible uses in addressing specific health conditions and needs.

Summary and Conclusions

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MK-677, also known as Ibutamoren, is a growth hormone secretagogue that has gained popularity for its potential benefits related to muscle growth, sleep, and anti-aging. Through various studies and anecdotal evidence, it has shown the promise to impact several aspects of overall well-being. In this summary, we will briefly review the observed effects, side effects, and relevant considerations when using MK-677.

Observed Effects:

  • Muscle growth: MK-677 has been reported to promote lean muscle mass by increasing growth hormone and IGF-1 levels, which are crucial for muscle growth and recovery.
  • Sleep quality: Users have experienced improved sleep patterns, which is essential for mental and physical recovery.
  • Anti-aging: By raising growth hormone levels, MK-677 may promote youthful skin, hair, and nails.
  • Cognitive function: Some studies suggest that MK-677 may have a positive impact on memory and cognitive function.

Side Effects:

However, it is essential to be aware of the possible side effects as well. Some commonly reported side effects include:

  • Increased appetite
  • Water retention and bloating
  • Mild joint pain
  • Temporary lethargy

It is crucial to follow the recommended dosage to minimize the likelihood of experiencing these side effects.

Dosage and Administration:

Typically, the suggested dosage for MK-677 ranges from 10 to 25 mg per day. This may vary according to individual goals, tolerance, and response. It is also advisable to start at a lower dosage and gradually assess the impact on the body.

In conclusion, while MK-677 has shown promise in various aspects of health and performance, it is vital to consider its potential side effects and to approach its use with caution. Consulting with a healthcare professional before beginning a regimen with MK-677 is highly recommended.

Frequently Asked Questions

What is the optimal dosage for MK-677?

The optimal dosage of MK-677 (Ibutamoren) varies depending on the user’s experience level. For beginners, a daily dose of 10mg is recommended. Intermediate users may increase the dosage to 25mg per day, and advanced users can opt for a daily dose of 50mg. It is essential to start with a lower dose and gradually increase it to determine the most suitable dosage for individual needs.

How long does it take to see results from Ibutamoren?

Results from MK-677 usage may vary among individuals, with some noticing changes within a few weeks, while others may take longer. Generally, it may take around six weeks for noticeable effects, such as increased muscle mass and improved sleep quality.

Can one expect permanent gains from MK-677?

MK-677 can provide temporary increases in growth hormone levels and muscle mass, but gains may not be permanent. Once the user stops taking the supplement, growth hormone levels will gradually decrease, and muscle gains might reverse over time. To maintain the results, individuals should continue with their regular workout and nutrition routines.

A typical cycle length for Ibutamoren may range from 8 to 12 weeks. Users should carefully monitor their progress and assess the benefits and side effects during the cycle to determine the most appropriate duration. It is also advisable to take breaks between cycles to allow the body to recover and maintain hormonal balance.

Are there any side effects associated with MK-677 use?

MK-677 is generally well-tolerated; however, some side effects may occur. These can include water retention, increased appetite, lethargy, numbness or tingling in extremities, and joint pain. Most side effects are mild and may resolve on their own. If any severe or persistent side effects appear, users should discontinue use and consult with a physician.

How does Ibutamoren compare to other similar supplements?

MK-677 (Ibutamoren) stands out as a growth hormone secretagogue, which effectively stimulates the release of growth hormone and increases IGF-1 levels. Unlike other supplements, it is orally active, making it easy to ingest and more convenient. Its impact on muscle growth, sleep quality, and overall performance make it a popular choice among bodybuilders and athletes. It is essential to note that individual results may vary, and users should thoroughly research other supplements to determine the best option for their needs.


  1. MK-677 Dosage Guide | Bodybuilding, Cycling, and Safety 2

  2. The Safety and Efficacy of Growth Hormone Secretagogues

  3. Beyond the androgen receptor: the role of growth hormone secretagogues 2

  4. Growth hormone secretagogue MK-677: no clinical effect on AD progression – PubMed

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