Ligandrol, also known as LGD-4033, is a popular selective androgen receptor modulator (SARM) that has gained traction among bodybuilders and athletes for its muscle-building and performance-enhancing effects. As a potent SARM, it binds to androgen receptors in the body, promoting anabolic activity and leading to impressive gains in muscle mass and strength. Many users have reported noticeable changes in their physiques both before and after using Ligandrol, showcasing its effectiveness in enhancing body composition and athletic performance.

However, as with any performance-enhancing substance, there are potential risks and side effects to consider before embarking on a Ligandrol cycle. Some common side effects include testosterone suppression, liver toxicity, and changes in cholesterol levels. It is also worth noting that since Ligandrol is relatively new and not yet approved for human consumption, caution is advised, and proper post-cycle therapy (PCT) should be implemented to ensure a safe and optimal recovery.
Key Takeaways
- Ligandrol (LGD-4033) is a potent SARM that promotes muscle growth and performance enhancement.
- Users may experience potential side effects such as testosterone suppression and liver toxicity, so caution is advised.
- Post-cycle therapy (PCT) is crucial for a safe recovery and optimal results after a Ligandrol cycle.
Understanding Ligandrol LGD-4033
Chemical Profile and Mechanism
Ligandrol (LGD-4033) is a selective androgen receptor modulator (SARM) developed by Ligand Pharmaceuticals. It is designed to deliver the anabolic effects of androgenic drugs while minimizing the undesirable side effects. As a non-steroidal modulator, Ligandrol binds to the androgen receptor with high affinity and triggers the receptor to stimulate muscle growth and bone mineralization.
The mechanism of action of Ligandrol involves selective tissue targeting and ligand specificity. This results in significant anabolic effects, promoting muscle growth, and bone strength while reducing negative impacts on other tissues.
Comparison to Anabolic Steroids
Unlike anabolic steroids, which have a broad range of actions in the body, Ligandrol and other SARMs exhibit tissue selectivity. This means they mainly target specific tissues, such as muscle and bone, leading to fewer side effects compared to steroids.
Anabolic Steroids vs. Ligandrol:
Aspect | Anabolic Steroids | Ligandrol (LGD-4033) |
---|---|---|
Tissue selectivity impact | Limited or No selectivity | High tissue selectivity |
Side effects | Wide range of side effects | Minimal side effects |
Anabolic effects | Strong anabolic effect | Strong anabolic effect |
Androgenic effects | Often strong androgenic effect | Very low or negligible androgenic effect |
Tissue Selectivity and SARMs
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Selective Androgen Receptor Modulators (SARMs) like Ligandrol offer promising potential due to their tissue selectivity. This means that they primarily target specific tissues such as muscle and bone, while avoiding negative impacts on other tissues like the liver, prostate, and heart.
Advantages of tissue selectivity in SARMs:
- Increased muscle mass
- Improved bone health
- Reduced undesirable side effects
- Enhanced recovery and performance potential
By selectively targeting the androgen receptor in muscle and bone, Ligandrol and other SARMs can offer significant benefits for those looking to enhance their physique, improve athletic performance, or recover from injury with fewer risks associated with traditional anabolic steroids.
Ligandrol Benefits and Effects
Muscle Mass Gains
Ligandrol (LGD-4033) is known for its ability to promote significant muscle mass gains. This selective androgen receptor modulator (SARM) works by binding to androgen receptors, resulting in an increase in anabolic activity within the body. In various studies, participants have experienced an increase in lean muscle mass after using Ligandrol. According to one source, users have reported muscle mass gains of up to 10 pounds within an 8-week cycle.
Strength Enhancement
Another key benefit of Ligandrol is its potential to enhance strength. Users have reported notable strength gains during their cycles, allowing them to lift heavier weights and perform more intensive workouts. In a study, participants experienced increased muscular strength after a 30-day use of LGD-4033.
Fat Loss and Body Composition
Ligandrol has also shown positive effects on fat loss and overall body composition. Although it is not primarily recognized as a fat-burning substance, its ability to build lean muscle mass and increase strength can indirectly lead to fat loss. As users gain muscle and improve their workouts, a higher metabolism and increased calorie expenditure can contribute to a more favorable body composition. A source mentioned that users have reported lower body fat percentages after using Ligandrol in combination with a proper diet and exercise regimen.
It’s important to note that while Ligandrol does offer these benefits, its potential side effects are still not completely understood. Users should be aware of the potential risks and always follow a safe and controlled cycle to minimize any adverse effects.
Administering Ligandrol For Best Results


Dosage Guidelines
When using Ligandrol (LGD-4033), it’s essential to follow proper dosage guidelines to ensure safety and achieve desired results. The recommended starting dosage is 5 mg per day. However, some users might increase the dosage to 10 mg per day for better results, depending on their goals, experience, and tolerance level1. It is crucial to consult a healthcare professional before starting any cycle to determine the most suitable dosing regimen for your individual needs.
Cycle Length and Protocol
The typical cycle length for Ligandrol ranges from 8 to 12 weeks2. It is recommended to start with a shorter cycle for beginners, gradually increasing the cycle duration as the user becomes more experienced and comfortable with the compound. To minimize potential side effects, a post-cycle therapy (PCT)3 should be conducted after the cycle, allowing the body to recover and restore natural hormone levels.
Stacking with Other SARMs
Many users choose to stack Ligandrol with other selective androgen receptor modulators (SARMs) to maximize benefits and achieve their desired outcomes. Some common stacks include:
- Ligandrol and Ostarine (MK-2866): This combination is popular for both bulking and cutting cycles, providing enhanced muscle mass, strength, and fat loss4.
- Ligandrol and Cardarine (GW-501516): Often used for cutting cycles, this stack helps preserve muscle mass while increasing fat loss and endurance5.
- Ligandrol and MK-677 (Ibutamoren): This stack promotes growth hormone release, leading to increased muscle mass, accelerated recovery, and improved sleep quality6.
Always remember to start with the lowest dosages and cycle durations when stacking SARMs, gradually adjusting them based on individual goals and responses to the compounds.
Before and After Results
Analyzing User Progress
LGD-4033, also known as Ligandrol, is a selective androgen receptor modulator (SARM) that helps users achieve amazing muscle gains, reduced body fat, and increased strength. As a nonsteroidal drug, Ligandrol is effective and safe for individuals looking for a reliable alternative to steroids.
To better understand the effectiveness of Ligandrol results, let’s take a closer look at before and after progress:
- Muscle gains: Users of Ligandrol typically see significant muscle mass increases within a short period, often in just a few weeks.
- Body fat reduction: Along with muscle growth, Ligandrol also helps individuals lose body fat by increasing their metabolism.
- Weight gain: Though Ligandrol increases muscle mass, the overall weight gain might not necessarily be as significant due to the simultaneous decrease in body fat.
It is important to remember that results may vary from person to person depending on factors such as consistency, training intensity, diet, and age.
Case Studies and Testimonials
Various case studies and testimonials reflect the effectiveness of Ligandrol in providing users with impressive gains and overall body transformation. The following examples showcase some of the most common changes observed in users after using Ligandrol:
- Increased muscle mass: Many users report noticeable muscle growth, with some experiencing up to 22mg gains within the cycle.
- Enhanced libido: Due to the drug’s anabolic effects, Ligandrol helps improve libido and sexual performance.
- Shortened recovery times: Ligandrol aids users in experiencing faster muscle recovery, allowing them to work out more intensively and consistently.
- Improved strength: Users generally experience a significant increase in strength and stamina, which further enhances their ability to work out harder.
In conclusion, before and after results from Ligandrol showcase the drug’s potential in helping users achieve an overall better physique, increased strength, and improved physical performance.
Potential Side Effects and Risks
Short Term Adverse Effects
Ligandrol, also known as LGD-4033, is a selective androgen receptor modulator (SARM) known for its muscle-building properties. However, it may also come with some short-term side effects. Users have reported experiencing dry mouth, muscle biopsy-related pain, and upper respiratory tract infections. In addition, temporary changes in cholesterol levels have been observed during Ligandrol use, though more research is needed to determine the long-term implications of this effect.
Long Term Health Implications
One of the significant concerns surrounding Ligandrol is its potential to cause liver toxicity. A case has been reported of severe liver injury linked to Ligandrol use. This highlights the need for caution when using this substance, as well as the importance of thoroughly monitoring liver function during its use.
Additionally, testosterone suppression may occur with Ligandrol use, which could have long-term implications on hormonal balance and overall health. However, the extent of this suppression and its potential consequences are still being researched.
Lastly, it is crucial to note that the long-term health implications of Ligandrol usage remain largely unknown, as comprehensive studies and extensive research on the substance are limited. As a result, users should approach Ligandrol with caution and consider the potential risks.
Managing Side Effects
- Closely follow recommended dosages: Minimize the risk of side effects by adhering to the suggested dosages.
- Monitor liver function: Regularly check serum aminotransferases and other liver function indicators to detect any signs of hepatotoxicity early.
- Report adverse effects: Consult a healthcare professional if you notice any worrisome side effects, particularly those relating to liver health or hormonal changes.
- Discontinue use if necessary: If severe side effects occur or persist, stopping Ligandrol usage is recommended.
Post Cycle Therapy (PCT)
Necessity of PCT After Ligandrol
Ligandrol (LGD-4033) is a popular SARM used to enhance muscle growth, endurance, and recovery time. One concern that arises after a cycle of Ligandrol is the potential suppression of natural testosterone levels. In some cases, this suppression can be significant, leading to the need for a post-cycle therapy (PCT) to restore hormonal balance1.
A study suggests that if you adhere to proper dosages and use high-quality Ligandrol, you may not need a PCT. However, it is important to monitor any suppressive symptoms, such as mood changes, fatigue, or decreased libido2. A blood test is ideal for determining whether your testosterone levels have dropped and if a PCT is necessary.
Common PCT Protocols
There are several common PCT protocols to ensure a smooth and speedy recovery after a Ligandrol cycle. Two of the most popular substances used in PCT protocols are Nolvadex and Clomid3. These drugs are known as Selective Estrogen Receptor Modulators (SERMs) and help restore testosterone production.
Nolvadex: This drug is commonly used in PCT due to its ability to block the effects of estrogen in the body, promoting natural testosterone production and preventing gynecomastia4. A typical Nolvadex PCT protocol runs for 4 weeks with the following dosages:
- Week 1: 40 mg per day
- Weeks 2-3: 20 mg per day
- Week 4: 10 mg per day
Clomid: Clomid is another popular choice in PCT, as it stimulates both follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn promotes increased testosterone production5. A common Clomid PCT protocol also lasts 4 weeks with the following dosages:
- Week 1: 50 mg per day
- Weeks 2-4: 25 mg per day
It is important to note that individual responses to PCT protocols can vary. Factors such as cycle length, dosage, and personal physiology play a role in determining the most effective post-cycle therapy. Consult a healthcare professional before starting any PCT to ensure the optimal course of action.
Supplementation and Diet


Nutritional Support for Best Results
To achieve the best results from a Ligandrol cycle, it is crucial to have a well-balanced diet that supports muscle growth and overall health. Adequate protein intake is essential for muscle recovery, growth, and maintenance, and should be a key component of your diet plan. Consuming at least 1 gram of protein per pound of body weight is a common recommendation for those aiming to increase muscle mass.
Carbohydrates play a vital role in providing energy for workouts and fueling muscle recovery. A diet rich in complex carbohydrates, such as whole grains, fruits, and vegetables, can help maintain consistent energy levels throughout the day. Healthy fats, like those found in avocados, nuts, and olive oil, should also be included as they are crucial for hormone production and overall health.
Hydration is another critical aspect of your diet, as it helps in maintaining optimal performance and reducing the risk of injury. Be sure to drink plenty of water, aiming for at least 8 glasses a day.
Complementary Supplements
Along with a well-balanced diet, incorporating complementary supplements can help maximize the results of a Ligandrol cycle. Here are some supplements to consider:
- Creatine: Commonly used to enhance muscle strength and size, creatine works by increasing the availability of adenosine triphosphate (ATP) in muscle cells, which supports muscle energy and performance. Adding 5 grams of creatine daily to your supplement regimen can boost both strength and longevity in workouts.
- Branched-Chain Amino Acids (BCAAs): BCAAs, particularly leucine, isoleucine, and valine, have been shown to promote muscle protein synthesis and reduce muscle soreness. Supplementing with BCAAs can help improve recovery and support muscle growth during a Ligandrol cycle.
- Fish Oil: Rich in omega-3 fatty acids, fish oil can help reduce inflammation, support brain function, and improve cardiovascular health. It may also play a role in enhancing muscle recovery and reducing muscle soreness post-exercise.
- Multivitamin: To ensure you get adequate amounts of essential vitamins and minerals, consider including a daily multivitamin in your supplement regimen. This can help fill any nutritional gaps and support overall health and wellbeing.
Remember to consult with a healthcare professional before starting any new supplement routine, especially alongside a Ligandrol cycle. Combining a well-planned diet with strategic supplementation can provide crucial support throughout your Ligandrol journey and maximize your before and after results.
Legal and Regulation Status
Legality Across Countries
Ligandrol (LGD-4033) is a selective androgen receptor modulator (SARM) that has gained popularity among athletes and bodybuilders due to its muscle-building and fat-burning properties. Despite its potential benefits, the legality of Ligandrol varies across countries. In the United States, Ligandrol is not approved for human consumption, but it is available for research purposes only. Sales and distribution for the purpose of human ingestion are illegal.
In Australia, Ligandrol is considered a Schedule 9 substance, meaning it is illegal to possess, import, or distribute without a valid prescription or permit. In the United Kingdom, however, the sale of Ligandrol is not explicitly illegal, but it is not authorized for human consumption. Individuals who purchase the substance must do so for research purposes only, and it must not be used for personal consumption.
Use in Sports and Athletics
The use of Ligandrol in sports and athletics is a contentious issue. In fact, it has been banned by the World Anti-Doping Agency (WADA) due to its potential performance-enhancing effects. As a result, many sports organizations, including the International Olympic Committee (IOC), have also prohibited its use by athletes.
In order to enforce these regulations, various sports technology laboratories have developed methods to detect the presence of Ligandrol in an athlete’s system. These tests can identify traces of this substance, thus ensuring fairness in sports competitions and preventing athletes from gaining an unfair advantage.
The prohibition of Ligandrol in athletics has not stopped its use, however. There have been instances where athletes have tested positive for this substance, leading to suspensions or other disciplinary actions. For instance, a placebo-controlled randomized clinical trial involving 76 healthy men concluded that LGD-4033 could cause liver injury when consumed in doses higher than recommended for research purposes. This further strengthens the call for increased monitoring and regulation of Ligandrol use in the sports world.
In conclusion, it is essential for athletes and fitness enthusiasts to be aware of the legal and regulatory status of Ligandrol in their respective countries, as well as its potential health risks. Additionally, individuals should refrain from using this substance unless it is necessary for research or prescribed by a medical professional.
Final Thoughts and Considerations


Ligandrol (LGD-4033) has been popular among bodybuilders for its potential to increase muscle mass and strength without the side effects commonly associated with anabolic steroids1. Although confidence in its efficacy remains high within the fitness community, it is essential to consider scientific evidence before making any decision.
Bodybuilders use Ligandrol primarily during bulking and cutting phases. During bulking, this Selective Androgen Receptor Modulator (SARM) may help users gain lean muscle mass2. Cutting, on the other hand, refers to the process of losing excess body fat while preserving muscle. Ligandrol’s potential ability to protect muscle tissue during periods of caloric deficit2 is especially beneficial during this stage.
Some anecdotal reports indicate that Ligandrol may improve recovery times1. Faster recovery allows for more frequent and intense workouts, contributing to increased muscle growth and overall performance.
However, it is crucial to note that most available data on Ligandrol is based on animal studies or early-stage human trials3. More robust human studies are needed to confirm its safety and efficacy fully.
Benefits | Considerations |
---|---|
Increased muscle mass1 | Limited human studies3 |
Improved strength1 | Possible side effects2 |
Faster recovery times1 | World Anti-Doping Agency ban4 |
In conclusion, Ligandrol shows promise for bodybuilders and athletes looking to improve their physique and performance. However, the limited research and potential side effects warrant caution. Always consult with a healthcare professional before starting any supplement regimen.
Natural supplement designed to legally mimic the muscle-building and fat loss effects of Ligandrol (LGD-4033) without the side effects.
Frequently Asked Questions


What is the recommended dosage for LGD-4033 to see effective results?
The recommended dosage for LGD-4033 (Ligandrol) varies depending on factors such as individual goals and tolerance levels. However, a common dosage range is between 5mg and 10mg per day for a cycle lasting 8-12 weeks. It is important to start with a lower dosage to assess tolerance and gradually increase as needed. It’s also essential to consult a healthcare professional before starting any new supplement regimen.
Can you describe the benefits one might expect from an LGD-4033 cycle?
LGD-4033 has been known to provide several potential benefits, including increases in lean muscle mass, muscular strength, and overall physical performance. It has also been reported to promote fat loss and improve recovery times after workouts. However, individual results may vary, and it is essential to maintain a proper diet and exercise routine to optimize the potential benefits of an LGD-4033 cycle.
Is post-cycle therapy (PCT) necessary after using LGD-4033, and why?
Post-cycle therapy (PCT) is often recommended after using LGD-4033. This is because LGD-4033 can potentially suppress natural testosterone production, which can lead to hormonal imbalances. A PCT aims to help restore the body’s natural hormone levels and minimize potential side effects. The specific PCT protocol may vary depending on factors such as the duration and dosage of the LGD-4033 cycle, as well as individual responses to the substance.
What differences in results can one expect from an LGD-4033 4-week cycle versus a longer cycle?
Shorter cycles, such as a 4-week LGD-4033 cycle, may yield smaller gains in muscle mass and strength compared to a longer cycle (e.g., 8-12 weeks). Longer cycles can potentially provide more significant results in terms of muscle growth and performance improvements. However, they may also increase the risk of side effects and require a more extended period of post-cycle therapy.
How does LGD-4033 compare to RAD 140 in terms of efficacy and safety?
Both LGD-4033 and RAD 140 are selective androgen receptor modulators (SARMs) known for their potential to increase muscle mass and strength. LGD-4033 is typically regarded as milder in terms of its effects, making it a suitable option for beginners or those seeking moderate muscle growth. In contrast, RAD 140 has been reported to have higher anabolic activity, potentially leading to more significant gains in muscle and strength but with an increased risk of side effects. It’s essential to consider individual goals, tolerance levels, and potential risks when comparing these two SARMs.
What is the typical half-life of LGD-4033, and how does it influence dosing schedules?
The half-life of LGD-4033 is approximately 24 hours, which means that it can be effectively dosed once per day. Due to its relatively long half-life, consistent daily dosing can help maintain stable blood levels of the substance, maximizing potential benefits while minimizing the risk of side effects.
Footnotes
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SARMs Before And After: 14 Photos of User Cycle Results ↩ ↩2 ↩3 ↩4 ↩5 ↩6 ↩7
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Ligandrol (LGD-4033 Results): What You Can Expect From Your First Cycle ↩ ↩2 ↩3 ↩4 ↩5
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LGD 4033 (Ligandrol): Side Effects, Dosage, & Before and After Pictures ↩ ↩2 ↩3 ↩4
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8 Stunning LGD 4033 (Ligandrol) Before And After Results With Pics ↩ ↩2 ↩3